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AS601245

Chemical Structure : AS601245

CAS No.: 345987-15-7

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AS601245 (AS-601245)

Catalog No.: PC-42785Not For Human Use, Lab Use Only.

AS601245 is a potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $328 In stock
50 mg $548 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AS601245 is a potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively.
AS601245 is less potent for c-Src, c-Raf, p38a kinases.
AS601245 exhibits in vitro and in vivo anti-inflammatory potential.

Physicochemical Properties

M.Wt 372.4462
Formula C20H16N6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

2-Benzothiazoleacetonitrile, -[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-

References

1. Gaillard P, et al. J Med Chem. 2005 Jul 14;48(14):4596-607.

2. Carboni S, et al. J Pharmacol Exp Ther. 2004 Jul;310(1):25-32.

3. Carboni S, et al. Br J Pharmacol. 2008 Jan;153(1):157-63.

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