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Cat. No. Product Name CAS No. Information
PC-43332

CC-401 hydrochloride

1438391-30-0

CC-401 hydrochloride is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases, including p38, ERK, IKK2, PK C, Lck, and ZAP70; decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in vivo; blocks JNK signaling in the rat obstructed kidney and significantly inhibits renal fibrosis in terms of interstitial myofibroblast accumulation and collagen IV deposition, also significantly reduces tubular apoptosis in the obstructed kidney; sensitizes hypoxic colon cancer cells to DNA-damaging agents, potentiates the effect of bevacizumab and oxaliplatin in HT29-derived mouse xenografts.

Blood Cancer

Phase 1 Discontinued

PC-63199

CC-401

395104-30-0

CC-401 (JNK-401) is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases; blocks JNK signaling and renal fibrosis in a rat obstructed kidney model, decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.

Blood Cancer

Phase 1 Discontinued

PC-43490

JNK-IN-8

1410880-22-6 JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively; exhibits exceptional selectivity based upon KinomeScan and enzymatic profiling; inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively.
PC-43238

SR-3306

1128096-91-2 SR-3306 is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38; shows cell-based IC50 of 216 nM, protects dopaminergic neurons against MPTP neurotoxicity in vitro and in vivo, achieves dopaminergic neuronal survival in the 6-OHDA model; also prevents ROS increases and mitochondrial dysfunction.
PC-42856

SP600125

129-56-6 SP600125 is a potent, selective, reversible, ATP-competitive inhibitor of JNK with IC50 of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively; displays 300-fold selectivity against related MAP kinases ERK1 and p38, and PKA; dose dependently inhibits the phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-γ, TNF-α, and prevents the activation and differentiation of primary human CD4 cell cultures; blocks LPS-induced expression of TNF-α and inhibits anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes in vivo model of endotoxin-induced inflammation.
PC-42552

BI-78D3

883065-90-5 A small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM; targets the JNK-JIP interaction site and dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell; blocks JNK dependent Con A-induced liver damage, restores insulin sensitivity in mouse models of type 2 diabetes.
PC-42095

IQ-1S

23146-22-7 A potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively; does not inhibits other kinases that represent potential targets for RA treatment, including GSK-3beta, JAK2, JAK3, PI3Ks, Btk, IKK-2, etc.; inhibits pro-inflammatory cytokine (IL-1α, IL-1β, IL-6, IL-10, TNF-α, IFN-γ, and GM-CSF and nitric oxide production by human and murine monocyte/macrophages; inhibits LPS-induced TNF-α and IL-6 production in MonoMac-6 cells with IC50 of 0.25 and 0.61 uM, respectively; reduces inflammation and cartilage loss associated with CIA in mice model.

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