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Chemical Structure : ASB17061
Catalog No.: PC-73065Not For Human Use, Lab Use Only.
ASB17061 (ASB-17061) is an orally active, selective chymase inhibitor with IC50 of 0.03 uM and 0.02 uM for mMCP-4 and human chymase, respecitvely.
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ASB17061 (ASB-17061) is an orally active, selective chymase inhibitor with IC50 of 0.03 uM and 0.02 uM for mMCP-4 and human chymase, respecitvely.
ASB17061 display little to no acitivites against bovine α-chymotrypsin, human cathepsin G, bovine trypsin and human elastase (all IC50> 1 uM).
ASB17061 significantly suppressed angiotensin II-induced abdominal aortic aneurysm (AAA) formation in apolipoprotein E-deficient mice at 10 mg/kg/
ASB17061 inhibited the accumulation of pro-MMP-9-producing cells in AAA lesions.
| M.Wt | 560.048 | |
| Formula | C27H34ClN5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tomimori Y, et al. Eur J Pharmacol. 2019 Aug 5;856:172403.
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