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Chemical Structure : ASC inhibitor MM01
CAS No.:
Catalog No.: PC-72648Not For Human Use, Lab Use Only.
ASC inhibitor MM01 (MM01) is a first-in-class, specific small-molecule inhibitor of ASC protein that interferes with ASC speck formation, inhibited ASC-mediated pro-Casp-1 activation with IC50 of 0.5 uM.
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| 10 mg | $958 | In stock | |
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ASC inhibitor MM01 (MM01) is a first-in-class, specific small-molecule inhibitor of ASC protein that interferes with ASC speck formation, inhibited ASC-mediated pro-Casp-1 activation with IC50 of 0.5 uM.
MM01 does not target the active site of caspase-1.
MM01 (10 uM) inhibits ASC oligomerization/speck formation and facilitates ASC degradation in HEK293 cells.
MM01 inhibits ASC-dependent inflammasome activity, inhibits NLRP3-dependent inflammasome activity in vitro.
MM01 inhibits ASC-dependent inflammasome activity in stimulated murine peritoneal macrophages and in MSU-induced peritonitis mouse model.
MM01 (10mg/kg) efficiently suppressed MSU-induced IL-1β production and peritoneal neutrophil recruitment, with no effect on IL-6 and TNF-α secretion in murine mono-sodium urate (MSU)-induced model of peritonitis.
ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD)) is a protein of the innate immune system that participates in the formation of inflammasomes, which are macromolecular complexes responsible for the maturation and release of pro-inflammatory cytokines.
| M.Wt | 318.37 | |
| Formula | C14H10N2O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3-(4-oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)propanal |
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1. Soriano-Teruel PM, et al. Cell Death Dis. 2021 Dec 13;12(12):1155.
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