ASM127 | NUDT5 PROTAC | Probechem Biochemicals

You are here:Home-ADCs and PROTACs-PROTAC-ASM127

Chemical Structure : ASM127

ASM127 (ASM-127)

Catalog No.: PC-27887Not For Human Use, Lab Use Only.

ASM127 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 12 nM in HEK293 cells (20h incubation), Dmax=71%.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ASM127 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 12 nM in HEK293 cells (20h incubation), Dmax=71%.

Physicochemical Properties

M.Wt	950.79
Formula	C42H45Cl2N11O11
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-8-(4-(3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoyl)piperazin-1-yl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

References

1. Marques AMC, et al. Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response. Nat Commun. 2026 Jun 30;17(1):8192.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

ASM127 (ASM-127)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.