ASM130 | NUDT5 PROTAC | Probechem Biochemicals

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Chemical Structure : ASM130

ASM130 (ASM-130)

Catalog No.: PC-27888Not For Human Use, Lab Use Only.

ASM130 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 7 nM in HEK293 cells (20h incubation), Dmax=73%.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ASM130 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 7 nM in HEK293 cells (20h incubation), Dmax=73%.

Physicochemical Properties

M.Wt	994.84
Formula	C44H49Cl2N11O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-8-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

References

1. Marques AMC, et al. Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response. Nat Commun. 2026 Jun 30;17(1):8192.

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ASM130 (ASM-130)

Biological Activity

Physicochemical Properties

References

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