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Chemical Structure : ASN 90
Catalog No.: PC-73139Not For Human Use, Lab Use Only.
ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM.
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ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM.
ASN90 does not inhibit hexosaminidase (Hex).
ASN90 induced protein O-GlcNAcylation in plated human and rodent PBMC with similar potencies (EC50 of 209 and 489 nM for human and rodent PBMC, respectively).
ASN90 is chemically distinct from carbohydrate-type substrate mimetic OGA inhibitors such as Thiamet G and MK-8719. ASN90 binds to the OGA enzyme in the living rat brain and robustly elevates the O-GlcNAcylation of brain proteins, including both tau and α-synuclein, in vivo.
ASN90 exhibited therapeutic efficacy in preclinical models of both tau and α-synuclein pathology.
| M.Wt | 375.447 | |
| Formula | C17H21N5O3S | |
| Appearance | Solid | |
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1. Permanne B, et al. ACS Chem Neurosci. doi: 10.1021/acschemneuro.2c00057.
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