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Chemical Structure : ASP2205
Catalog No.: PC-73306Not For Human Use, Lab Use Only.
ASP2205 (ASP2205 fumarate) is a potent, selective 5-HT2C receptor agonist with EC50 of 0.85/2.5 nM for human/rat 5-HT2C in the intracellular Ca2+ mobilization assays, respectively.
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ASP2205 (ASP2205 fumarate) is a potent, selective 5-HT2C receptor agonist with EC50 of 0.85/2.5 nM for human/rat 5-HT2C in the intracellular Ca2+ mobilization assays, respectively.
ASP2205 showed partial agonistic action on human 5-HT2A receptor with EC50 of 96 nM, no agonistic action against 5-HT2B.
ASP2205 (0.1-1 mg/kg, i.d.) significantly elevated the leak point pressure (LPP) in anesthetized rats in a dose-dependent manner.
ASP2205 is a more potent and selective 5-HT2C receptor agonist than lorcaserin.
| M.Wt | 416.518 | |
| Formula | C23H32N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ishigami T, et al. J Pharmacol Sci. 2019 Apr;139(4):333-339.
2. Klarskov N, et al. Neurourol Urodyn. 2019 Aug;38(6):1700-1706.
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