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ASP 2905

Chemical Structure ASP 2905

CAS No.: 792184-90-8

ASP 2905 (ASP2905;ASP-2905)

Catalog No.: PC-60984Not For Human Use, Lab Use Only.

ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats.

Alzheimer Disease

Phase 1 Discontinued

Physicochemical Properties

M.Wt 388.41
Formula C20H17FN8
CAS No. 792184-90-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

Clinical Information

References

1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35.

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