| Cat. No. |
Product Name |
Information |
| PC-20745 |
LAKI
TREK channel inhibitor
|
LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels. |
| PC-49538 |
SCR2682
Kv.7 activator
|
SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine. |
| PC-49461 |
C101248
THIK-1 inhibitor
|
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1. |
| PC-47105 |
TTQC-1
BKCa activator
|
TTQC-1 is a potent activator of the large-conductance Ca2+-activated K+ channel (BKCa channel), directly and reversibly activates the macroscopic current of BKCa channels expressed in Xenopus oocytes from both sides of the cellular membrane, increases the maximum conductance and shifted the half activation voltage to the left with EC50 of 2.8 uM. |
| PC-47099 |
SKA-31
KCa2/KCa3.1 activator
|
SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively. |
| PC-38847 |
ZVS-08
Kv10.1 inhibitor
|
ZVS-08 is a selective inhibitor of the voltage-gated potassium channel KV10.1 with IC50 of 3.7 uM. |
| PC-73240 |
VU0606170
KNa1.1 (Slack) inhibitor
|
VU 0606170 is a selective sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) inhibitor with EC50 of 1.84 and 1.16 uM for WT Slack and A934T Slack, repectively. |
| PC-73230 |
Benzopyran-G1
IKACh inhibitor
|
Benzopyran-G1 is a selective inhibitor of cardiac acetylcholine-activated inwardly rectifying K+ current (IKACh), composed of Kir3.1/Kir3.4 heterotetrameric and Kir3.4 homotetrameric channel subunits. |
| PC-73196 |
Encukalner
KCNQ2/3 activator
|
Encukalner (KCNQ2/3 activator-1) is a small molecule activator of Kv7.2/Kv7.3 (KCNQ2/3) potassium channel with potential for relieving pain. |
| PC-73038 |
Kv2.1-syntaxin inhibitor 15
Kv2.1-syntaxin inhibitor
|
Kv2.1-syntaxin inhibitor 15 (Kv2.1-syntaxin-IN-15, Cpd5) is a small molecule Kv2.1-syntaxin-binding inhibitor (IC50=5.5 uM) with neuroprotective properties. |
| PC-72872 |
VU6036720
Kir4.1/Kir5.1 inhibitor
|
VU6036720 (VU 6036720) is the first potent, selective inhibitor of heteromeric Kir4.1/Kir5.1 (KCNJ10/KCNJ16) with IC50 of 0.24 uM. |
| PC-72820 |
VU0468554
GIRK inhibitor
|
VU0468554 (VU 0468554) is a nove potent, selective inhibitor of GIRK channel with IC50 of 0.85 and 2.6 uM for GIRK1/GIRK4 and GIRK1/GIRK2 in cellular assays. |
