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Chemical Structure : ASP 7663
Catalog No.: PC-61156Not For Human Use, Lab Use Only.
A novel potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively.
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A novel potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively; concentration-dependently stimulates 5-HT release from QGP-1 cells with EC50 of 72.5 uM, significantly improves the loperamide-induced delay in colonic transit in mice, also significantly inhibits colorectal distension (CRD)-induced abdominal pain response in rats.
| M.Wt | 263.268 | |
| Formula | C14H14FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kojima R, et al. Eur J Pharmacol. 2014 Jan 15;723:288-93.
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