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Chemical Structure : AT-IAP
Catalog No.: PC-60254Not For Human Use, Lab Use Only.
A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively.
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AT-IAP is a potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively.
AT-IAP exhibits MDA-MB-231 cell proliferation inhibition with IC50 of 4.4 nM.
AT-IAP decreases basal and TNF-α-induced cIAP-1 expression in CaP cells, switches TNF-α signaling from pro-survival to pro-apoptotic and increases radiation sensitivity of CaP cells in co-culture with THP-1 cells.
AT-IAP shows in vivo efficacy in Balb/c scid mice bearing MDA-MB-231 xenografts.
| M.Wt | 509.67 | |
| Formula | C29H40FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tamanini E, et al. J Med Chem. 2017 Jun 8;60(11):4611-4625.
2. Armstrong CW, et al. Oncotarget. 2016 Feb 16;7(7):7885-98.
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