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Chemical Structure : AT13148
CAS No.: 1056901-62-2
Catalog No.: PC-20556Not For Human Use, Lab Use Only.
AT13148 (AT 13148) is a potent, ATP-competitive and orally active multi-AGC kinase inhibitor with IC50 vaules of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $688 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AT13148 (AT 13148) is a potent, ATP-competitive and orally active multi-AGC kinase inhibitor with IC50 vaules of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
AT13148 potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines.
AT13148 dramatically suppresses activation of multiple AGC kinases, including Akt (at p-Thr-308), p70S6 kinase (p70S6K), glycogen synthase kinase 3β (GSK-3β) and p90 ribosomal S6 kinase (RSK) in gastric cancer cells.
AT13148 (40 and 50 mg/kg p.o.) inhibits phosphorylation of the AKT substrates GSK3β, tuberin, and the p70S6K target S6RP are also observed in PTEN-deficient MES-SA human uterine tumor xenografts.
AT13148 significantly inhibits HGC27 xenograft tumor growth in nude mice.
| M.Wt | 313.79 | |
| Formula | C17H16ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O[C@@](C1=CC=C(Cl)C=C1)(CN)C2=CC=C(C3=CNN=C3)C=C2 |
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1. Yap TA, et al. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.
2. Xi Y, et al. Biochem Biophys Res Commun. 2016 Sep 9;478(1):330-6.
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