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Chemical Structure : AUT1
CAS No.: 1311136-84-1
Catalog No.: PC-60647Not For Human Use, Lab Use Only.
AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively.
AUT1 displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters.
AUT1 increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM.
AUT1 rescues the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline.
| M.Wt | 341.367 | |
| Formula | C18H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione |
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1. Rosato-Siri MD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.
2. Brown MR, et al. J Neurophysiol. 2016 Jul 1;116(1):106-21.
3. Parekh PK, et al. Neuropsychopharmacology. 2018 Jan;43(2):435-444.
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