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Chemical Structure : AV-412 free base
CAS No.: 451492-95-8
Catalog No.: PC-42546Not For Human Use, Lab Use Only.
AV-412 free base (MP412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AV-412 free base (MP412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively.
AV-412 also inhibits Abl (IC50=41 nM), weakly inhibits Flt3 and Src.
AV-412 inhibits autophosphorylation of EGFR and ErbB2 with IC50 of 43 and 282 nM.
AV-412 inhibits EGF-dependent cell proliferation with IC50 of 100 nM; active in cancer xenograft models.
| M.Wt | 507.0022 | |
| Formula | C27H28ClFN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO：≥ 50 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]- |
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1. Suzuki T, et al. Cancer Sci. 2007 Dec;98(12):1977-84.
2. Suzuki T, et al. Cancer Sci. 2009 Aug;100(8):1526-31.
3. Zhou Y, et al. Nat Biotechnol. 2010 Jan;28(1):71-8.
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