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Chemical Structure : AVN-944
CAS No.: 297730-17-7
Catalog No.: PC-49656Not For Human Use, Lab Use Only.
AVN-944 (VX-944) is a potent, selective, noncompetitive inhibitor of both human inosine 5-monophosphate dehydrogenase (IMPDH) isoforms (Ki=6-10 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $248 | In stock | |
| 25 mg | $448 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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AVN-944 (VX-944) is a potent, selective, noncompetitive inhibitor of both human inosine 5-monophosphate dehydrogenase (IMPDH) isoforms (Ki=6-10 nM).
AVN-944 (VX-944) significantly inhibited the growth of MM cell lines RPMI8226, MM.1S, and U266 cells in a dose-dependent fashion with IC50 of 450, 450, and 600 nM (48h),respectively.
AVN-944 (VX-944) also inhibited growth of drugresistant cell lines, including doxorubicin (Dox)-resistant RPMI8226-Dox40, melphalan (Mel) resistant
RPMI8226-LR5, and Dex (dexamethasone) resistant MM.1R cells, with IC50 values similar to the parental drug-sensitive cell lines.
AVN-944 (VX-944) induced caspase-independent apoptosis in MM cells, induced modest cleavage of caspase 3, 8 and 9, enhances expression of Bax and Bak proteins.
AVN-944 (VX-944) augmented the cytotoxicity of doxorubicin and melphalan even in the presence of BMSCs.
AVN-944 (VX-944) also inhibits ZIKV Replication against ZIKV Paraiba/2015 in A549 cells.
| M.Wt | 477.52 | |
| Formula | C25H27N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R)-1-(Cyanomethyl)propyl N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]carbamate |
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1. Kenji Ishitsuka, et al. Oncogene. 2005 Sep 1;24(38):5888-96.
2. Park JG, et al. J Virol. 2020 Mar 17;94(7):e02149-19.
3. Morales Vasquez D, et al. Viruses. 2020 Sep 18;12(9):1041.
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