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Chemical Structure : AZ-23
CAS No.: 915720-21-7
Catalog No.: PC-63210Not For Human Use, Lab Use Only.
AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $298 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | $898 | In stock | |
| 1 g | $898 | In stock |
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AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively.
AZ-23 displays >10-fold specificity for TrkA versus FGFR1 and >25-fold over a broad panel of kinases.
AZ-23 potently inhibits NGF-induced TrkA/B/C phosphorylation in NIH-3T3 cells with IC50 of 2 nM, 25-fold window of selectivity versus FGFR, Flt3, Ret, and Lck kinases.
AZ-23 exhibits significant tumor growth inhibition in Trk-expressing xenograft model of neuroblastoma.
| M.Wt | 391.83 | |
| Formula | C17H19ClFN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 5-chloro-N2-((1S)-1-(5-fluoro-2-pyridinyl)ethyl)-N4-(5-(1-methylethoxy)-1H-pyrazol-3-yl)- |
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1. Thress K, et al. Mol Cancer Ther. 2009 Jul;8(7):1818-27.
2. Wang T, et al. J Med Chem. 2008 Aug 14;51(15):4672-84.
3. Chen S, et al. Cell Oncol (Dordr). 2018 Feb;41(1):93-101.
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