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Chemical Structure : AZ1729
Catalog No.: PC-63157Not For Human Use, Lab Use Only.
AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways.
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AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways.
AZ1729 produces stimulation of [35S]GTPγS binding with pEC50 7.23.
AZ1729 inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils.
| M.Wt | 369.418 | |
| Formula | C18H16FN5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bolognini D, et al. J Biol Chem. 2016 Sep 2;291(36):18915-31.
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