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Chemical Structure : AZ5104
CAS No.: 1421373-98-9
Catalog No.: PC-63158Not For Human Use, Lab Use Only.
AZ 5104 is the active metabolite of AZD 9291 (Osimertinib), which is an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50=15-17 nM) that spares the wild-type form of the receptor (IC50=480 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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AZ 5104 is the active metabolite of AZD 9291 (Osimertinib), which is an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50=15-17 nM) that spares the wild-type form of the receptor (IC50=480 nM).
AZ5104 inhibits cellular growth in Ex20Ins mutant cell lines in vitro and demonstrate sustained tumor growth inhibition of EGFR-mutant tumor xenograft harboring the most prevalent Ex20Ins in vivo.
| M.Wt | 485.592 | |
| Formula | C27H31N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide |
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1. Yates JW, et al. Mol Cancer Ther. 2016 Oct;15(10):2378-2387.
2. Hanker AB, et al. Cancer Discov. 2017 Jun;7(6):575-585.
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