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Chemical Structure : AZD-1305
Catalog No.: PC-63154Not For Human Use, Lab Use Only.
AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes.
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AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes。
AZD-1305 significantly prolongs action potential duration and reduces excitability at 0.1-10 uM in dogs.
AZD-1305 effectively prevents induction of persistent acetylcholine-mediated atrial fibrillation (AF) in vivo.
| M.Wt | 434.512 | |
| Formula | C22H31FN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sicouri S, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):255-9.
2. Burashnikov A, et al. J Cardiovasc Pharmacol. 2010 Jul;56(1):80-90.
3. Johnson DM, et al. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):201-9.
4. Geller JC, et al. J Clin Pharmacol. 2009 Mar;49(3):312-22.
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