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Chemical Structure : AZD0449
Catalog No.: PC-49307Not For Human Use, Lab Use Only.
AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3.
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AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3.
AZD0449 inhibited JAK1-dependent signaling, determined by reductions in IL-4-induced STAT6 phosphorylation in human CD4+ T cells with IC50 of 21.4 nM, inhibited IL-13-induced phosphorylation of STAT6- and TSLP-induced production of CCL17.
AZD0449 dose-dependently inhibited STAT3, STAT5a, and STAT5b phosphorylation in lung tissue from ovalbumin (OVA)-challenged rats.
AZD0449 also inhibited eosinophilia in the lung and reduced the late asthmatic response, measured as Penh in the OVA rat model.
| M.Wt | 375.432 | |
| Formula | C21H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Magnus Nilsson, et al. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917.
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