Catalog No.: PC-24525Not For Human Use, Lab Use Only.
AZD0780 (AZD-0780) is a potent, orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with Kd of <200 nM, binds to a novel pocket in the PCSK9 C-terminal domain and does not affect the PCSK9-LDL receptor (LDLR) interaction.
AZD0780 (AZD-0780) is a potent, orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with Kd of <200 nM, binds to a novel pocket in the PCSK9 C-terminal domain and does not affect the PCSK9-LDL receptor (LDLR) interaction. AZD0780 inhibits lysosomal trafficking of PSCK9-LDLR complexes and prevents PCSK9-induced LDLR degradation. AZD0780 demonstrated robust, dose-dependent reductions in LDL-C with a favorable safety and tolerability profile supporting further development of this once daily, oral treatment in clinical investigations.
