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You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-JAK-AZD4604
AZD4604

Chemical Structure : AZD4604

CAS No.: 2241039-81-4

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AZD4604 (AZD-4604, AZD 4604)

Catalog No.: PC-72603Not For Human Use, Lab Use Only.

AZD4604 (AZD-4604) is a, potent, highly selective, ATP-competitive and oral JAK1 inhibitor with IC50 of 0.54 nM, shows >1000-fold selectivity over other JAK family members.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZD4604 (AZD-4604) is a, potent, highly selective, ATP-competitive and oral JAK1 inhibitor with IC50 of 0.54 nM, shows >1000-fold selectivity over other JAK family members.
AZD4604 effectively inhibits the differentiation of Th1, Th2, and Th17 cells as indicated by a dose-dependent decrease in the production of Th-specific signature cytokines including reduction in IL-4, IL-5, and IL-13 productions by Th2 cells.
AZD4604 significantly blocks IL-4-induced STAT6 phosphorylation in CD4+ T cells.
AZD4604 blocks IL-13-induced STAT6 phosphorylation in monocytes with IC50 of 28 nM.
AZD4604 shows anti-inflammatory effect.

Physicochemical Properties

M.Wt 599.658
Formula C28H31F2N7O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(3-(5-fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide

References

1. Magnus Nilsson, et al. J Med Chem. 2023 Sep 22. doi: 10.1021/acs.jmedchem.3c00554.

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