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Chemical Structure : AZD5305
CAS No.: 2589531-76-8
Catalog No.: PC-72405Not For Human Use, Lab Use Only.
AZD5305 (AZD-5305) is a potent, selective, orally active PARP1 inhibitor (IC50=3 nM) and PARP1-DNA trapper.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $348 | In stock | |
| 25 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZD5305 (AZD-5305) is a potent, selective, orally active PARP1 inhibitor (IC50=3 nM) and PARP1-DNA trapper.
AZD5305 is highly selective for PARP1 over other PARP family members (PARP2 IC50=1.4 uM), with good secondary pharmacology and physicochemical properties and excellent pharmacokinetics in preclinical species.
AZD5305 reduced effects on human bone marrow progenitor cells in vitro, showed excellent in vivo efficacy in a BRCA mutant HBCx-17 PDX model.
| M.Wt | 406.49 | |
| Formula | C22H26N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)-N-methylpicolinamide |
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1. Jeffrey W Johannes, et al. J Med Chem. 2021 Oct 14;64(19):14498-14512.
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