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Chemical Structure : AZD5904
CAS No.: 618913-30-7
Catalog No.: PC-35219Not For Human Use, Lab Use Only.
AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat.
AZD5904 displays 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase, >70-fold to a broad panel of other enzymes, ion channels, and receptors.
AZD5904 (1 µM) inhibited PMA stimulated HOCl by >90% in isolated human neutrophils.
AZD5904 has a plasma concentration of ~5 µM decreased the in vivo formation of glutathione sulphonamide in rats.
| M.Wt | 252.292 | |
| Formula | C10H12N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- (9CI) |
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