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Chemical Structure : AZD 7009
Catalog No.: PC-63155Not For Human Use, Lab Use Only.
AZD 7009 is a novel antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM.
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AZD 7009 is a novel antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM; also inhibits late sodium current in isolated rabbit atrial and ventricular myocytes, attenuates the E-4031-induced action potential duration prolongation, induces early afterdepolarisations (EADs) in Purkinje fibres.
Heart Arrhythmia
Phase 2 Discontinued
| M.Wt | 446.548 | |
| Formula | C23H34N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goldstein RN, et al. J Cardiovasc Electrophysiol. 2004 Dec;15(12):1444-50.
2. Persson F, et al. J Cardiovasc Electrophysiol. 2005 Mar;16(3):329-41.
3. Persson F, et al. J Cardiovasc Pharmacol. 2005 Jul;46(1):7-17.
4. Persson F, et al. Eur J Pharmacol. 2007 Mar 8;558(1-3):133-43.
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