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Chemical Structure : AZD7687
Catalog No.: PC-20386Not For Human Use, Lab Use Only.
AZD7687 (AZD-7687) is a potent, selective DGAT1 inhibitor with IC50 of 80 nM (hDGAT1), >400-fold selectivity over hACAT1.
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AZD7687 (AZD-7687) is a potent, selective DGAT1 inhibitor with IC50 of 80 nM (hDGAT1), >400-fold selectivity over hACAT1.
AZD7687 potently inhibits human DGAT1 liver microsome with IC50 of 70 nM, and higher inhibitory potency against human adipose tissue with IC50 of 10 nM.
AZD7687 only shows little to no inhibition of ACAT (79% at 10 μM), FAAH (IC50 = 3.7 μM), muscarinic M2 receptor (IC50 = 80.5 μM), and PDE10A1 in a panel of 339 in vitro radioligand binding and enzyme assays.
| M.Wt | 367.45 | |
| Formula | C21H25N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barlind JG, et al. J Med Chem. 2012 Dec 13;55(23):10610-29.
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