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Chemical Structure : AZD9898
Catalog No.: PC-73115Not For Human Use, Lab Use Only.
AZD9898 (AZD-9898) is a highly potent, selective and oral inhibitor of leukotriene C4 synthase (LTC4S) with IC50 of 0.28 nM.
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AZD9898 (AZD-9898) is a highly potent, selective and oral inhibitor of leukotriene C4 synthase (LTC4S) with IC50 of 0.28 nM.
AZD9898 displays nanomolar potency in cells (PBMCs, IC50,free = 6.2 nM).
AZD9898 exhibits good in vivo pharmacodynamics in a calcium ionophore-stimulated rat model after oral dosing (in vivo, IC50,free = 34 nM).
| M.Wt | 457.834 | |
| Formula | C20H19ClF3N3O4 | |
| Appearance | Solid | |
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1. Munck Af Rosenschöld M, et al. J Med Chem. 2019 Sep 12;62(17):7769-7787.
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