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Chemical Structure : AZSMO-23
Catalog No.: PC-60836Not For Human Use, Lab Use Only.
AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.
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AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.
AZSMO-23 increases pre-pulse current at +40 mV by 952% and tail current at −30 mV by 238% at 100 uM.
AZSMO-23 blocks the mutant channel hERG Y652A, but shows enhanced activator activity against another mutant channel hERG F656T.
AZSMO-23 also blocks hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activated hCav1.2/β2/α2δ channels.
| M.Wt | 348.79 | |
| Formula | C19H13ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mannikko R, et al. Br J Pharmacol. 2015 Jun;172(12):3112-25.
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