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Chemical Structure : Abequolixron
CAS No.: 610318-54-2
Catalog No.: PC-38644Not For Human Use, Lab Use Only.
RGX-104 (Abequolixron) is a small-molecule liver X receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the apolipoprotein E (ApoE) gene, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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RGX-104 (Abequolixron) is a small-molecule liver X receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the apolipoprotein E (ApoE) gene, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.
RGX-104 (Abequolixron) activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment.
RGX-104 (Abequolixron) selectively targets and binds to LXRbeta (NR1H2), thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes.
| M.Wt | 596.087 | |
| Formula | C34H33ClF3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid |
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1. Liang H, et al. Biochem Biophys Res Commun. 2020 Jul 23;528(2):330-335.
2. Emerson Lim, et al. Cancer Res (2020) 80 (16_Supplement): CT146.
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