| Cat. No. |
Product Name |
Information |
| PC-49867 |
GAC0001E5
LXR inverse agonist
|
GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM). |
| PC-63084 |
GSK-2033
LXR antagonist
|
GSK-2033 (GSK2033) is the first potent, cell-active LXR antagonist with binding pIC50 of 7.0/7.5 for LXRα/LXRβ, respectively. |
| PC-63083 |
SR9238
LXR inverse agonist
|
SR9238 is the first selective synthetic LXR inverse agonist with IC50 of 214 nM and 43 nM for LXRα and LXRβ, respectively. |
| PC-61598 |
LXRβ agonist 17
LXRβ agonist
|
LXRβ agonist 17 is a potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα. |
| PC-61593 |
BMS-852927
LXRβ agonist
|
BMS-852927 (XL041) is a highly potent liver X receptor β (LXRβ) agonist with Ki of 12 and 19 nM for LXRβ and LXRα, respectively. |
| PC-42686 |
GW3965 hydrochloride
LXR agonist
|
GW3965 hydrochloride is a potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM. |
| PC-42685 |
GW3965
LXR agonist
|
GW3965 is a potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM. |
| PC-45748 |
BMS-779788
LXR agonist
|
BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM). |
| PC-45444 |
AZ-876
LXR agonist
|
AZ-876 (AZ876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. |
| PC-42684 |
T0901317
LXR agonist
|
T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively). |
| PC-45108 |
SR9243
LXR inverse agonist
|
SR9243 is a potent LXR inverse agonist that inhibits LXR activation by enhancing LXR-corepressor recruitment. |
| PC-42687 |
LXR-623
LXR agonist
|
LXR-623 (WAY 252623) is a clinically viable, highly brain-penetrant LXRα-partial/LXRβ-full agonist with binding Ki of 33 nM/248 nM, respectively. |
