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Chemical Structure : Adavosertib
CAS No.: 955365-80-7
Catalog No.: PC-42770Not For Human Use, Lab Use Only.
Adavosertib (AZD-1775;MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Adavosertib (AZD-1775, MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.
Adavosertib (AZD-1775, MK-1775) exhibits ATP-competitive and highly selective against other serine/threonine or tyrosine kinases.
Adavosertib (AZD-1775, MK-1775) inhibits phosphorylation of CDC2 at Tyr15 in cells;.
Adavosertib (AZD-1775, MK-1775) potentiates tumor growth inhibition in vivo.
| M.Wt | 500.5954 | |
| Formula | C27H32N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- |
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1. Hirai H, et al. Mol Cancer Ther. 2009 Nov;8(11):2992-3000.
2. Hirai H, et al. Cancer Biol Ther. 2010 Apr 1;9(7):514-22.
3. Bridges KA, et al. Clin Cancer Res. 2011 Sep 1;17(17):5638-48.
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