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Chemical Structure : Afatinib
CAS No.: 850140-72-6
Catalog No.: PC-42499Not For Human Use, Lab Use Only.
Afatinib (BIBW 2992) is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.
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Afatinib (BIBW 2992) is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.
Afatinib (BIBW 2992) shows high selectivity over HGFR, c-Src, β-InsRK,VEGFR2.
Afatinib (BIBW 2992) suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines and induces tumor regression in xenograft and transgenic lung cancer models.
| M.Wt | 485.9384 | |
| Formula | C24H25ClFN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)- |
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1. Li D, et al. Oncogene. 2008 Aug 7;27(34):4702-11.
2. Perera SA, et al. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9.
3. Takezawa K, et al. Mol Cancer Ther. 2010 Jun;9(6):1647-56.
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