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Chemical Structure : Afatinib dimaleate
CAS No.: 850140-73-7
Catalog No.: PC-42500Not For Human Use, Lab Use Only.
Afatinib (BIBW 2992) dimaleate is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $120 | In stock | |
| 200 mg | $168 | In stock | |
| 1 g | Get quote |
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Afatinib (BIBW 2992) dimaleate is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.
Afatinib shows high selectivity over HGFR, c-Src, β-InsRK,VEGFR2.
Afatinib suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines and induces tumor regression in xenograft and transgenic lung cancer models.
| M.Wt | 718.0827 | |
| Formula | C32H33ClFN5O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2) (9CI) |
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1. Li D, et al. Oncogene. 2008 Aug 7;27(34):4702-11.
2. Perera SA, et al. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9.
3. Takezawa K, et al. Mol Cancer Ther. 2010 Jun;9(6):1647-56.
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