Catalog No.: PC-28290Not For Human Use, Lab Use Only.
Agrimol B is a polyphenol derived from Agrimonia pilosa Ledeb., significantly induces cytoplasm-to-nucleus shuttle of SIRT1, inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression, blocks adipogenesis at the early stage of differentiation with IC50 of 3.35 uM.
Agrimol B is a polyphenol derived from Agrimonia pilosa Ledeb., significantly induces cytoplasm-to-nucleus shuttle of SIRT1, inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression, blocks adipogenesis at the early stage of differentiation with IC50 of 3.35 uM.
Agrimol B induces autophagic death in TP53-mutant pancreatic cancer by targeting the S100A6-HDAC2-mutant p53 acetylation axis.
Agrimol B downregulates the protein level of NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1) through caspase 3-mediated degradation, leading to mitochondrial reactive oxygen species (mROS) accumulation and autophagy arrest.
Agrimol B significantly enhances the sensitivity of HCC cells to sorafenib in vitro and in vivo.
Agrimol B inhibits the growth and proliferation of HCC cells in vitro as well as in an HCC patient-derived xenograft (PDX) model.
