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Chemical Structure : Allitinib
CAS No.: 897383-62-9
Catalog No.: PC-60010Not For Human Use, Lab Use Only.
Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $628 | In stock | |
| 500 mg | Get quote |
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Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays; also inhibits ErbB4 (IC50=0.8 nM), displays >3,000-fold selectivity over other kinase families; exhibits strong antiproliferative effects on a panel of cancer cell lines, and potently suppresses tumor growth in vivo; orally available.
Solid Tumors
Phase 1 Clinical
| M.Wt | 448.877 | |
| Formula | C24H18ClFN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide |
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1. Xie H, et al. PLoS One. 2011;6(7):e21487.
2. Zhang H, et al. Cancer Lett. 2014 Aug 1;350(1-2):61-8.
3. Zhang J, et al. J Hematol Oncol. 2014 Mar 11;7:22.
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