Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Almonertinib
CAS No.: 1899921-05-1
Catalog No.: PC-38342Not For Human Use, Lab Use Only.
Aumolertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations with IC50 of 0.37 nM (T790M), 0.21 nM (del19/T790M), 0.29 nM(L858R/T790M), and 3.39 nM (EGFR WT).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $218 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | $858 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Aumolertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations with IC50 of 0.37 nM (T790M), 0.21 nM (del19/T790M), 0.29 nM(L858R/T790M), and 3.39 nM (EGFR WT).
In cell-based assays, almonertinib inhibits EGFR phosphorylation at IC50 of 3.3 nM in HCC827 (EGFR del19) cell line, IC50 of 4.1 nM in PC9 (EGFR del19) cell line, IC50 of 3.3 nM in NCI-H1975 (EGFR L858R/T790M) cell line, but only IC50 of 596.6 nM in A431 (EGFR WT) cell line.
| M.Wt | 525.657 | |
| Formula | C30H35N7O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(5-((4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethyl-methylamino)-4-methoxyphenyl)prop-2-enamide |
|
1. Yang JC, et al. J Thorac Oncol. 2020 Dec;15(12):1907-1918.
2. Nagasaka M, et al. J Thorac Oncol. 2021 May;16(5):740-763.
3. Wu CP, et al. Biochem Pharmacol. 2021 Jun;188:114516.
4. Lu S, et al. J Thorac Oncol. 2022 Mar;17(3):411-422.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
