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Chemical Structure : Aminopyridine 2
Catalog No.: PC-35561Not For Human Use, Lab Use Only.
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.
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Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively; also inhibits eosinophil peroxidase (EPO, IC50=0.29 uM), and shows no apparent activity against other oxidases; blockes MPO-dependent vasomotor dysfunction ex vivo in rat aortic rings, also inhibits MPO activity in vivo in a mouse model of peritonitis.
| M.Wt | 321.178 | |
| Formula | C13H13BrN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marro ML, et al. J Pharmacol Exp Ther. 2018 Aug 3. pii: jpet.118.248435.
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