Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Amlexanox
CAS No.: 68302-57-8
Catalog No.: PC-20619Not For Human Use, Lab Use Only.
Amoxanox (AA-673) is a high affinity, specific inhibitor of IKKε and TBK1 with IC50 of 1-2 uM for both, without effect on IKKα or IKKβ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $98 | In stock | |
| 500 mg | $198 | In stock | |
| 1 g | $288 | In stock | |
| 5 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Amoxanox (AA-673) is a high affinity, specific inhibitor of IKKε and TBK1 with IC50 of 1-2 uM for both, without effect on IKKα or IKKβ.
Amoxanox (AA-673) reduces leukotriene D4- and platelet-activating factor-induced bronchoconstriction in guinea pigs, strongly suggesting an antagonistic activity against slow reacting substance of anaphylaxis.
Amoxanox (AA-673) is an approved small-molecule therapeutic presently used in the clinic to treat aphthous ulcers and asthma.
Amoxanox (AA-673) increases phosphorylation of TBK1 on Ser172 in 3T3-L1 adipocytes, and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a presumed substrate of IKKε and TBK1.
Amoxanox (AA-673) (25 mg/kg, daily gavage) prevents and reverses diet-induced or genetic obesity, improves insulin sensitivity and glucose tolerance in obese mice.
Amoxanox (AA-673) reverses hepatic steatosis, reduces chronic adipose tissue inflammation and promotes energy expenditure in adipose tissue in obese mice.
| M.Wt | 298.30 | |
| Formula | C16H14N2O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
O=C(C1=C(N)N=C2C(C(C3=CC(C(C)C)=CC=C3O2)=O)=C1)O |
|
1. T Saijo, et al. Int Arch Allergy Appl Immunol. 1985;77(3):315-21.
2. Zhang Y, et al. Sci Rep. 2015 Sep 4;5:13575.
3. Reilly SM, et al. Nat Med. 2013 Mar;19(3):313-21.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
