| Cat. No. |
Product Name |
Information |
| PC-49484 |
AFN700
IKKβ inhibitor
|
AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM. |
| PC-38171 |
GSK8612
TBK1 inhibitor
|
GSK8612 (GSK-8612) is a highly selective, potent TBK1 inhibitor, inhibits recombinant TBK1 with pIC50 of 6.8 in biochemical functional assays. |
| PC-35769 |
SR12343
IKKβ inhibitor
|
SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays. |
| PC-63330 |
IKK16
IKK inhibitor
|
IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. |
| PC-43329 |
BI605906
IKKβ inhibitor
|
BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
| PC-61282 |
AS602868
IKK2 inhibitor
|
AS602868 (SPC 839) is a potent, selective and ATP-competitive inhibitor of IKK2 with IC50 of 60 nM and Ki of 20 nM, also interfers directly with FLT3 kinase activation. |
| PC-61094 |
PHA-408
IKK2 inhibitor
|
PHA-408 (PHA-767408) is a potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1. |
| PC-61066 |
SU-909
IKKα inhibitor
|
SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM). |
| PC-60552 |
iNUB
NEMO inhibitor
|
iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM. |
| PC-45398 |
PS-1145
IKK inhibitor
|
PS-1145 (PS1145) is a specific IκB kinase (IKK) inhibitor with IC50 of 88 nM. |
| PC-43044 |
WS-3
|
WS3 is a small molecule that can induce proliferation of β cells with EC50 of 74 nM. |
| PC-45916 |
Bay 65-1942
IKKβ inhibitor
|
Bay 65-1942 (BAY651942) is a potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM. |
