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Chemical Structure : Antimalarial compound 49c
Catalog No.: PC-35257Not For Human Use, Lab Use Only.
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
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Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
Antimalarial compound 49c blocks invasion and egress of P. falciparum without impacting intraerythrocytic growth, specifically inhibits recombinant PfPMIX and PfPMX (r-PMIXFlag and r-PMXFlag), recapitulating the defect in invasion and egress of P. falciparum in the erythrocytic blood stages.
Antimalarial compound 49c also interferes with invasion and egress in T. gondii by targeting TgASP3
| M.Wt | 514.67 | |
| Formula | C31H38N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ciana C, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):658-62.
2. Mukherjee B, et al. EMBO J. 2018 Apr 3;37(7). pii: e98047.
3. Pino P, et al. Science. 2017 Oct 27;358(6362):522-528.
4. Dogga SK, et al. Elife. 2017 Sep 12;6. pii: e27480.
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