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Chemical Structure : Apatinib
CAS No.: 1218779-75-9
Catalog No.: PC-43506Not For Human Use, Lab Use Only.
Apatinib (YN968D1) is a multitargeted tyrosine kinase inhibitor (TKI) that inhibits VEGFR-2 (Flk-1/KDR, IC50=1 nM), RET, c-Kit and c-Src (IC50=13, 429 and 530 nM respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $188 | In stock | |
| 100 mg | $348 | In stock | |
| 500 mg | $758 | In stock |
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Apatinib (YN968D1) is a multitargeted tyrosine kinase inhibitor (TKI) that inhibits VEGFR-2 (Flk-1/KDR, IC50=1 nM), RET, c-Kit and c-Src (IC50=13, 429 and 530 nM respectively); significantly increases the accumulation of DOX and Rho 123 in cells overexpressing ABCB1 and ABCG2, inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ, effectively inhibits proliferation, migration and tube formation of HUVECs induced by FBS, and blocks the budding of rat aortic ring; effectively inhibits the growth of several human tumor xenograft models with little toxicity alone and in combination with chemotherapeutic agents.
Gastric Cancer
Approved
| M.Wt | ||
| Formula | C25H27N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-, methanesulfonate (1:1) |
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1. Mi YJ, et al. Cancer Res. 2010 Oct 15;70(20):7981-91.
2. Tian S, et al. Cancer Sci. 2011 Jul;102(7):1374-80.
3. Tong XZ, et al. Biochem Pharmacol. 2012 Mar 1;83(5):586-97.
4. Li J, et al. BMC Cancer. 2010 Oct 5;10:529.
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