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Chemical Structure : Apostatin-1
CAS No.: 2559703-06-7
Catalog No.: PC-38288Not For Human Use, Lab Use Only.
Apostatin-1 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
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| 25 mg | $298 | In stock | |
| 100 mg | $598 | In stock | |
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Apostatin-1 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
TRADD-N interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
Apostatin-1 effectively induced autophagy and the degradation of long-lived proteins.
Inhibition of TRADD by ICCB-19 or Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin.
| M.Wt | 345.502 | |
| Formula | C19H27N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide |
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1. Daichao Xu, et al. Nature. 2020 Nov;587(7832):133-138.
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