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Chemical Structure : Aprepitant
CAS No.: 170729-80-3
Catalog No.: PC-42185Not For Human Use, Lab Use Only.
Aprepitant (MK-0869) is a potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $178 | In stock | |
| 100 mg | $278 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Aprepitant (MK-0869) is a potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
Aprepitant (MK-0869) blocks NK-1 agonist-induced foot tapping response in gerbils and shows antiemetic actions in the ferret against cisplatin challenge.
Aprepitant (MK-0869) has the potentiation for the treatment of peripheral pain, migraine, chemotherapy-induced emesis, and various psychiatric disorders.
| M.Wt | 534.4266 | |
| Formula | C23H21F7N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro- |
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1. Kramer MS, et al. Science. 1998 Sep 11;281(5383):1640-5.
2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.
3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.
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