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Chemical Structure : Avadomide
CAS No.: 1015474-32-4
Catalog No.: PC-42180Not For Human Use, Lab Use Only.
Avadomide (CC-122) is a small molecule that binds to cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in DLBCL and T cells in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $378 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Avadomide (CC-122) is a small molecule that binds to cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in DLBCL and T cells in vitro and in vivo.
Avadomide (CC-122) induces degradation of transcription factors Aiolos (IKZF3) and Ikaros (IKZF1) and does not affect CK1α protein levels.
Avadomide (CC-122) inhibits proliferation and induces apoptosis in a broad panel of DLBCL cell lines, and stimulates IL-2 production in primary T cells.
Avadomide (CC-122) reduces tumor growth in xenograft models established from ABC- and GCB-DLBCL cell lines.
| M.Wt | 286.2859 | |
| Formula | C14H14N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)- |
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1. Hagner PR, et al. Blood. 2015 Aug 6;126(6):779-89.
2. Krönke J, et al. Nature. 2015 Jul 9;523(7559):183-188.
3. Chamberlain PP, et al. Nat Struct Mol Biol. 2014 Sep;21(9):803-9.
4. Koeller KM, et al. Chem Biol. 2003 May;10(5):397-410.
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