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Cat. No. Product Name CAS No. Information
PC-61056

VH 298

2097381-85-4

A potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays; selectively engages VHL as its prime cellular target and is not toxic to cells, induces concentration- and time-dependent on-target specific accumulation of hydroxylated HIF-α in human cell lines; induces HIF transcriptional activity and upregulates HIF-dependent response gene products, elicits a HIF-dependent hypoxic response in various cell lines.

PC-60125

CC-885

1010100-07-8

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1; The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1; promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1.

PC-60116

VH-032

1448188-62-2

VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.

PC-35014

VHL-alkyne

VHL-alkyne is a VHL ligand for PROTAC synthesis.
PC-62218

PROTAC-VHL-ligand

1448297-52-6 PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.
PC-60118

VHL Ligand 4

1631137-45-5 A VHL ligand for PROTAC.
PC-60117

VHL-2

1631137-31-9 A VHL ligand for PROTAC.

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