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Azvudine

Chemical Structure : Azvudine

CAS No.: 1011529-10-4

Azvudine (RO 0622)

Catalog No.: PC-63018Not For Human Use, Lab Use Only.

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM; inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=10-100 nM).

Physicochemical Properties

M.Wt 286.223
Formula C9H11FN6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

References

1. Klumpp K, et al. J Biol Chem. 2008 Jan 25;283(4):2167-75.

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