Chemical Structure : B0AT1 inhibitor compound 3
CAS No.:
2962069-39-0
B0AT1 inhibitor compound 3
Catalog No.: PC-27193Not For Human Use, Lab Use Only.
B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively.
B0AT1 inhibitor compound 3 shows high binding affinity with Kd of 47.0 nM in cell membrane-binding assays using human B0AT1-ACE2 co-expressing cells.
B0AT1 inhibitor compound 3 preferentially binds to the Na⁺-bound conformation of B0AT1.
B0AT1 inhibitor compound 3 treatment (30 mg/kg, oral) significantly increased urinary phenylalanine (Phe) excretion in phenylketonuria (PKU) model mice.
Physicochemical Properties
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M.Wt
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355.32
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Formula
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C16H16F3N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-(2-oxo-2-(3-oxopiperazin-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)acrylamide
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References
1. Takuya Imazu, et al. Commun Biol. 2026 Jun 25. doi: 10.1038/s42003-026-10535-y.
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