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Chemical Structure : BAA473
Catalog No.: PC-36008Not For Human Use, Lab Use Only.
BAA473 (BAA-473) is a bile acid analogue that functions as the first small molecule activator of the Pyrin inflammasome, induces secretion of IL18 in LPS-primed PBMCs.
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BAA473 (BAA-473) is a bile acid analogue that functions as the first small molecule activator of the Pyrin inflammasome, induces secretion of IL18 in LPS-primed PBMCs.
BAA473 activates inflammasome in both myeloid and intestinal epithelial cells, the CASP1 inhibitor VX-765 blocked BAA473-induced IL1β production in THP-1 cells.
BAA473 induces cytokine production via ASC/CASP1 but not NLRP3.
| M.Wt | 404.591 | |
| Formula | C25H40O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alimov I, et al. J Biol Chem. 2019 Jan 15. pii: jbc.RA118.005103.
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