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Chemical Structure : BAX inhibitor BAI1
CAS No.: 335165-68-9
Catalog No.: PC-72240Not For Human Use, Lab Use Only.
BAX inhibitor BAI1 (BAI1) is a small-molecule allosteric inhibitor of BAX, bind directly to BAX and inhibits tBID-induced BAX-mediated membrane permeabilization with IC50 of 3.4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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BAX inhibitor BAI1 (BAI1) is a small-molecule allosteric inhibitor of BAX, bind directly to BAX and inhibits tBID-induced BAX-mediated membrane permeabilization with IC50 of 3.4 uM.
BAI1 binds to inactive monomeric BAX at a novel allosteric site, allosterically inhibits BIM BH3-mediated BAX activation and oligomerization.
BAI1 selectively inhibited BAX-mediated apoptotic cell death, effectively inhibited TNFα + cyclohexamide mediated-apoptosis monitored by caspase 3/7 activation in a dose-dependent manner (IC50=1.8 uM).
| M.Wt | 467.205 | |
| Formula | C19H21Br2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol |
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1. Thomas P Garner, et al. Nat Chem Biol. 2019 Apr;15(4):322-330.
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